"Circulating vitamin D, the parent compound, likely plays an important physiological role with respect to the vitamin D endocrine/autocrine system . . . .for the optimal functioning of these systems, significant vitamin D should be available on a daily basis to ensure stable circulating concentrations"
"The distinct direct and indirect effects of 1α,25(OH)2D3 and 25OHD3 respectively on muscle function and gene expression suggest that multiple other factors must be considered when assessing the physiological impact of vitamin D deficiency or supplementation."
"vitamin D is also delivered directly to all tissues of the body. Many of these tissues . . .can convert vitamin D to its active form within the tissue. . . . Vitamin D has a half life in the autocrine system of roughly 24 hours, so in order for it to have a meaningful impact on cellular functions, you need a new supply of it every day."
"The more constant you can keep your vitamin D level the better equipped your body is to fight disease."
Source: GrassrootsHealth Newsletter, January 20, 2016
"the presumed inactive sterol, D3, is actually a potent and general mediator of endothelial stability at physiologically relevant concentrations"
“Vitamin D3, which is converted into the active form of vitamin D, suppressed protein insolubility in C. elegans and prevented the toxicity caused by human beta-amyloid which is associated with Alzheimer’s disease,” Prof. Lithgow said.
(note it was the "parent" form, Vitamin D3, prior to conversion to the "active" form that provided the benefits observed)
Vitamin D engaged with known longevity genes – it extended median lifespan by 33% and slowed the aging-related misfolding of hundreds of proteins"
“. . . if it’s a more global marker of health or longevity as this paper suggests, that’s a paradigm shift. Now we’re talking about something very different and exciting.”